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Microelectrode and voltage-clamp techniques were modified to record spontaneous electrical activity and ionic currents of Lymnea stagnalis neurons during exposure to a 900-MHz field in a waveguide-based apparatus. The field was pulse-modulated at repetition rates ranging from 0.5 to 110 pps, or it was applied as a continuous wave (CW). When subjected to pulsed waves (PW), rapid, burst-like changes in the firing rate of neurons occurred at SARs of a few W/kg. If the burst-like irregularity was present in the firing rate under control conditions, irradiation enhanced its probability of occurrence. The effect was dependent on modulation, but not on modulation frequency, and it had a threshold SAR near 0.5 W/kg. CW radiation had no effect on the firing rate pattern at the same SAR. Mediator-induced, current activation of acetyl-choline, dopamine, serotonin, or gamma-aminobutyric-acid receptors of the neuronal soma was not altered during CW or PW exposures and, hence, could not have been responsible for the bursting effect. 相似文献
74.
Gostyukhina A. A. Samoylova A. V. Bolshakov M. A. Mochalova V. M. Zaitsev K. V. Kutenkov O. P. Rostov V. V. 《Biology Bulletin》2022,49(5):532-537
Biology Bulletin - The effect of nanosecond repetitive pulsed microwave radiation (RPMR, 10 GHz, 100 ns pulse duration, 8 Hz pulse repetition rate, 140 and 1500 W/cm2 peak power flux density... 相似文献
75.
Kovalchuk L. A. Chernaya L. V. Mishchenko V. A. Berzin D. L. Bolshakov V. N. 《Doklady biological sciences》2022,505(1):100-104
Doklady Biological Sciences - A comparative analysis of hematological parameters was for the first time performed in two ectothermal amphibians of the Middle Ural fauna, the Siberian salamander... 相似文献
76.
Makhneva Zoya K. Smolova Tatyana N. Bolshakov Maksim A. Moskalenko Andrey A. 《Biochemistry. Biokhimii?a》2022,87(10):1159-1168
Biochemistry (Moscow) - It was established that in a heterogeneous model system, which consisted of two types of complexes: reaction center or core complex of photosystem 2 of higher plants and LH2... 相似文献
77.
Kovalchuk L. A. Chernaya L. V. Mishchenko V. A. Berzin D. L. Bolshakov V. N. 《Doklady. Biochemistry and biophysics》2021,500(1):327-330
Doklady Biochemistry and Biophysics - For the first time, the results of a comparative analysis of free amino acids in the blood plasma of amphibians of the Ural fauna are presented: an endemic... 相似文献
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TP Souza-Junior L Loren?o-Lima D Ganini CV Vardaris TG Polotow MP Barros 《Biology of sport / Institute of Sport》2014,31(4):271-276
Reactive oxygen species are produced during anaerobic exercise mostly by Fe ions released into plasma and endothelial/muscle xanthine oxidase activation that generates uric acid (UA) as the endpoint metabolite. Paradoxically, UA is considered a major antioxidant by virtue of being able to chelate pro-oxidative iron ions. This work aimed to evaluate the relationship between UA and plasma markers of oxidative stress following the exhaustive Wingate test. Plasma samples of 17 male undergraduate students were collected before, 5 and 60 min after maximal anaerobic effort for the measurement of total iron, haem iron, UA, ferric-reducing antioxidant activity in plasma (FRAP), and malondialdehyde (MDA, biomarker of lipoperoxidation). Iron and FRAP showed similar kinetics in plasma, demonstrating an adequate pro-/antioxidant balance immediately after exercise and during the recovery period (5–60 min). Slight variations of haem iron concentrations did not support a relevant contribution of rhabdomyolysis or haemolysis for iron overload following exercise. UA concentration did not vary immediately after exercise but rather increased 29% during the recovery period. Unaltered MDA levels were concomitantly measured. We propose that delayed UA accumulation in plasma is an auxiliary antioxidant response to post-exercise (iron-mediated) oxidative stress, and the high correlation between total UA and FRAP in plasma (R-Square = 0.636; p = 0.00582) supports this hypothesis. 相似文献
80.
A. E. Bolshakov D. A. Sibarov P. A. Abushik I. I. Krivoi S. M. Antonov 《Biochemistry (Moscow) Supplemental Series A: Membrane and Cell Biology》2012,6(4):294-299
Effects of 0.01 nM–1 nM ouabain on neuronal survival in excitotoxic stress and ouabain self toxic action in concentrations from 10 nM to 30 μM were studied. Neuronal viability was evaluated by measuring Bcl-2 protein expression and using vital staining test allowing recognition of live, necrotic and apoptotic cells. Excitotoxic stress was induced by 240-min treatment with agonists of ionotropic glutamate receptors (NMDA or kainate). Experiments were performed on rat primary neuronal cultures of 7–14 DIV (days in vitro). Thirty μM NMDA induced apoptosis in 45 ± 9% (n = 5), and 30 μM kainate, in 52 ± 5% (n = 5) of neurons. An antiapoptotic effect of ultra low (0.01 nM–1 nM) ouabain concentrations was found to restore Bcl-2 expression and to bring apoptosis level back to control values (about 10%, n = 5). Since in this concentration range ouabain is not able to inhibit NKA, we conclude that neuroprotection discloses the signaling function of NKA. Whereas ouabain self toxic action in higher concentrations (10 nM–30 μM, during 240 min) resulted in necrotic death of 45% neurons (apoptosis remained as under the control conditions), the large portion of neurons were unaffected. The relatively low threshold concentration of ouabain toxic action (10 nM) is consistent with the sensitivity to ouabain of α3-isoform of NKA. Thus, ouabain was found to have a bimodal effect, including antiapoptotic action in excitotoxic stress in the concentration range from 0.01 nM to 1 nM, and self toxic action at larger concentrations. Self toxicity of ouabain is initiated through inhibition of NKA pumping function. Neuronal heterogeneity with respect to ouabain toxic action is probably related with the different expression of α1 and α3-isoforms of NKA in pyramid neurons and interneurons. 相似文献